Presently, there are many researches done in field of Guillain Barre Syndrome. The most common frequently done research is on pulmonary complications and extended use of ventilators. Patients with Guillain Barre Syndrome are weak to many complications like pulmonary complications and frequently need extended ventilator support. Exact research information on this ventilator administration on these patients is quite inadequate. Entire objective of this ventilator research is to get exact facts and figures of risk factors that are involved in Guillain Barre Syndrome and mortality rate and success ratio of the recovered patients. Some recent research confirms that numbness and weakness are the basic long term triggering side effects that prevail in few patients even years after the first attack of Guillain Barre Syndrome.
Today there is no exact treatment available however scientists are seeking new and innovative ways for cure of this fatal illness. Majority of Guillain Barre Syndrome patients experience pulmonary complications or digestive tract disorders. Respiratory infection is a life threatening problem and need immediate hospitalization. Intravenous immunoglobin and Plasmapheresis are generally administered to decrease the severity of Guillain Barre Syndrome and for fast full functional recovery.
The natural treatment of Guillain Barre Syndrome insists on treating the damage nerves that triggers numbness or paralysis. There are few herbal medicines like Trayodashang-Guggulu, Panch Tikta Ghrut Guggulu, Kaishor Guggulu, and Yograj Guggulu that are rarely used or treating symptoms of Guillain Barre Syndrome.
These natural or herbal medicines take longer time to treat the illness and often patient needs immediate care so best option obviously is the complete medical support with proper care not to mention the emergency ventilators support. Therefore it is a fatal illness and may cause sudden death due to pulmonary failure.
It is best to provide best hospitalization support to the patient to avoid further complications instead of relying on natural treatment.
Clinical Variants of Guillain Barre Syndrome!
During last few decades, numerous variants of Guillain Barre Syndrome are documented. These illness variants share similar patterns of symptom, development, recovery, overlap, and possible immune treatments. Presently there are six identified variants of Guillain Barre Syndrome.
1- Acute inflammatory demyelinating polyneuropathy or AIDP
Generally ADIP is more common type of Guillain Barre Syndrome. At the moment, there are many identified variants of Guillain Barre Syndrome, although majority of medical professionals consider AIDP as Guillain Barre Syndrome. Infrastructure and economical advancement of any country plays a vital rule in the ratio of people who suffer from Guillain Barre Syndrome, for example 1 case of GBS is reported in population of 25,000-170,000. The most common type of GBS variant affects people in old age, however this cruel disease is not limited to just old people, children and adults, male and female everyone gets same symptoms and similar severe complications.
2-Miller Fisher Syndrome
Miller Fisher Syndrome is another common clinical variant of Guillain Barre Syndrome, it’s identified in approximately in 5% of all Guillain Barre Syndrome cases. This syndrome include of areflexia, ataxia, and ophthalmoplegia. Initially it is noted between trunk and in the gait, it’s mainly involves lower limb. It speedily spread all over in the body damaging entire peripheral nerves. The average course of recovery may be different in various patients, few patients show fast recovery while others may suffer chronic symptoms of Guillain Barre Syndrome. There is a close connection between antiganglioside antibodies and the Miller Fisher Syndrome.
3- AMAN Variant
The AMAN variant is well connected with high titers of antibodies to gangliosides and enteric C jejuni infections. Patients with AMAN syndrome demonstrate similar signs as clinically appear in patients suffering with the demyelinating type of Guillain Barre Syndrome. AMAN is diagnosed by electrodiagnostic study results that are steady by speedy axonopathy.
4- Wallerianlike Degeneration
Wallerianlike Degeneration is another significant variant shown in Biopsies without lymphocyte inflammation. Several cases have been identified in rural areas of China, particularly in young adults and children in the summer months. Axonal cases may happen commonly outside of North America and Europe. There are also noticeable differences between AMAN from cases of axonal Guillain Barre Syndrome reported in the West. Frequently the Prognosis is rather productive, though time of complete recovery may be different in many patients. Some patients recover fast and show amazing recovery in few months while others may have to experience the painful complications even years of first attack
There are few leading hospitals and neurological clinics that mainly deal with patients with acute symptoms and signs of Guillain Barre Syndrome. Here are few leading medical clinics for Guillain Barre Syndrome where patients and their family can contact on following phone numbers for an appointment.
1. Mayo Clinic Arizona
Toll free # 1-800-446-2279 Mountain time between 8 a.m. and 5 p.m. Weekdays.
2. Mayo Clinic Minnesota
Toll free # 507-538-3270 Central time between 7 a.m. to 7 p.m. Weekdays.
3. Mayo Clinic Florida
Toll free # 904-953-0853 Eastern time between 8 a.m. and 5 p.m. Monday through Friday.
4. Cleveland Clinic, Ohio
Toll-Free: # 866.320.4573 Eastern time between 7 a.m. – 11 p.m. Mon. – Sun.
International Callers: +001 216.444.8184 Eastern time between 7 a.m. – 5 p.m.
5. Cleveland Clinic, Florida
Toll-Free # 877.463.2010 Eastern time between 7 a.m. – 6 p.m. Mon. – Fri. 8 a.m. – 12 p.m. Sat.
Closed Sun. and Holidays
6. Cleveland Clinic, Ontario, Canada
Toll-Free # 888.507.6885 Eastern time between 8 a.m. – 5 p.m. Mon. – Fri.
Plasmapheresis is a procedure, in which plasma the liquid part of the blood is separated from blood cells by a machine recognized as a cell separator. There are two procedures that are usually used to remove plasma from the blood, on the first method separator spins the blood at high speed to remove the cells from the plasma. In second method the blood pass through a membrane with tiny pores that filters blood cells from plasma. The cells collected in the Plasmapheresis are returned to the Guillain Barre Syndrome patient, although the plasma that includes the antibodies is useless and restored by other fluids. Patients suffering from Guillain Barre Syndrome are kept under strict medication and medical support to keep the blood from clotting, often an anticoagulant is transmitted through veins.
The process of Plasmapheresis takes several hours and be more convenient on outpatient basis. This treatment may be appears slightly uncomfortable however it’s usually not painful. The need of Plasmapheresis depends upon condition of patient and treatment recommended by neurological surgeon. Although an average time of plasma exchanges is 6-10 treatments within 2-10 weeks. In few Guillain Barre Syndrome centers, Plasmapheresis treatments are done once a week and in other hospitals treatment is done more than one weekly. Usually the patient undergoing plasmapheresis sits in a reclining chair or lie in bed. Catheter a small thin tube is inserted in a large vein, normally on the crook of the arm, and another Catheter is placed in the opposite hand or foot. Initially blood is transferred to the separator from one tube, as the removed blood cells are merged with replacement liquids and returned to the patient via other tube. The quantity of blood outside patient’s body is less than the amount usually donated during blood donation to blood banks. Are there any risks involve in Plasmapheresis? The answer is yes however these risks are easily controlled.